Weekley and de Jonge were atop the leaderboard at 8-under 64. Friday could find the course a bit different from the rain-softened surfaces of Thursday.
Weekley found new irons to his liking, delivering an eagle, seven birdies and a bogey. De Jonge, of Zimbabwe, had eight birdies at TPC Louisiana.
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Sean O’Hair and David Hearn of Canada started Friday a stroke behind the leaders at 65.
Among top-ranked players to watch on Friday: Dustin Johnson, No. 7 in the world, and Australia’s Jason Day, No. 6, who come off rounds of 67.
Ninth-ranked Justin Rose, No. 9 in the world, began Friday at 69. Rickie Fowler was even par, but he will need a much better second round to avoid missing the cut.
Rain halted play for about 90 minutes on Thursday, making a soggy course even wetter.