These tumors make up 0.3% to 0.9% of breast tumors. Most women who are diagnosed with phyllodes tumors are premenopausal (most commonly, in their 40s). In rare cases, adolescent girls may be diagnosed with this type of breast tumor. They are very rare in men.
Symptoms
Phyllodes tumors usually present themselves as firm, smooth-sided breast lumps. This type of breast tumor grows very quickly—so much so that the lump can become noticeably bigger in a couple of weeks. Breast skin over the tumor may become reddish and warm to the touch.
If you notice one during a self-breast exam, you should have it checked out as soon as possible. Untreated phyllodes tumors may break through the skin and create an ulcer.
Other symptoms may include those seen with breast cancers in general, including:
Swelling in part in all or part of the breastNipple or breast painNipple turning inwardSkin irritation or dimpling (orange peel texture)Redness, scaling, and thickening of nipple or breast skinNipple discharge (other than breast milk)An underarm lump
Causes
The causes of phyllodes tumors are unknown. They seem to be more common as people age. Certain factors may contribute to the growth of these tumors, including:
Being femaleInjury to the breastIncreased levels of the female hormone estrogenBreastfeedingPregnancy
Li-Fraumeni syndrome, an inherited genetic condition, also increases one’s risk of phyllodes tumors.
Diagnosis
Because phyllodes tumors are similar in presentation to fibroadenomas (i.e., firm, well-defined), these two conditions are often mistaken for one another.
Unfortunately, neither a mammogram nor breast ultrasound can clearly distinguish between the two (regardless of whether or not a phyllodes tumor, if present, is cancerous or not). Rather, an excisional biopsy is required.
Excisional Biopsy
Cells from a needle biopsy can be tested in the lab, but seldom give a clear diagnosis because they can resemble carcinomas and fibroadenomas. That is why an excisional biopsy is needed. It removes the entire lump (or area of abnormal tissue) and a portion of normal, healthy tissue for testing.
Once the sample is taken, a pathologist will look at the tissue under a microscope and classify the tumor as one of the following:
If a tumor is relatively small and benign, it may be removed with a lumpectomy. Large benign tumors may require a mastectomy to remove both the tumor and a clean margin of breast tissue.
Malignant tumors are removed with a wide local excision (WLE) or mastectomy to remove as much of the affected tissue as possible. Your healthcare provider may also suggest radiation therapy to keep the cancer from coming back.
Prognosis
Overall, the prognosis for benign phyllodes tumors is very good. Research shows an 8% rate of recurrence.
For people who have borderline or malignant phyllodes tumors, prognosis can vary, but is generally positive; most cases can be cured with the right treatment. However, it is possible for cells to remain after surgery, causing a tumor to recur even just a few years after surgery. Your healthcare provider will recommend close monitoring, including regular mammograms, to watch for tumor recurrence.
Malignant tumors may metastasize to the lungs, bones, liver, and chest wall. That said, few cases advance in this way, even though lymph nodes may be involved.
A Word From Verywell
If you notice any new signs or symptoms during a breast self-exam after a phyllodes tumor has been removed, it is a good idea to see to your healthcare provider immediately. While phyllodes tumors can recur, they often do not, and you should be assessed for other potential causes of your breast changes.
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